His doctor was calling him an asshole using medical terminology. Irritability is a very common sign and symptom of depression, but it's not a discrete diagnosis. His irritability is more likely the result of anything or anyone challenging his carefully constructed reality that he's on the same level as Stern.

I forget which comic it was, but on O&A, he refereed to "fibromyalga" as "whinypants disease". Seems apropos.

It's basically a polite medical way of telling somebody that they throw tantrums like a child when things aren't going well for them.

Idiot, he misspoke. He meant irritable Bowel syndrome.

Opie is irritable bowel syndrome!

No, this diagnosis does not exist.

Signed,

Licensed mental health clinician

Major Depressive Disorder can have the following specifiers: mild, moderate, severe, with psychotic features, in partial remission, in full remission, with anxious distress, with mixed features, with melancholic features, with atypical features (like leaden paralysis), with mood-congruent psychotic features, with mood-incongruent psychotic features, with catatonia, with peripartum onset and lastly and most commonly, with seasonal pattern.

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I looked it up right when he said it, seems like it's a thing. But I'd never heard of it.

Opie is irritable bowel syndrome!